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P1‐371: The Association Between Apathy and Executive Function in Coronary Artery Disease Patients is Modified By Endothelial Dysfunction
Author(s) -
Saleem Mahwesh,
Herrmann Nathan,
Dinoff Adam,
Mazereeuw Graham,
Oh Paul I.,
Goldstein Benjamin,
Lanctot Krista L.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1123
Subject(s) - apathy , executive dysfunction , endothelial dysfunction , medicine , coronary artery disease , cardiology , trail making test , cognition , reactive hyperemia , psychology , disease , physical therapy , cognitive impairment , psychiatry , neuropsychology , vasodilation
However, on the California Verbal Learning Test, SNAP (A-/N+) showed faster memory decline than the A-/Ngroup (p1⁄4.03), while A+/Ndid not (p1⁄4.37) (Figure 2). Conclusions: In the oldest-old, presence of both beta-amyloid and hippocampal atrophy combined confers the greatest risk for cognitive decline across domains. Isolated beta-amyloid is associated with decline on executive functions, while SNAP (isolated hippocampal atrophy) is associated with decline on verbal memory. Neither biomarker abnormality is benign in the 9 and 10 decades of life.