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IC‐P‐081: Quantification of White Matter Hyperintensities Using A Multi‐Modality Automated Segmentation Method
Author(s) -
Joules Richard,
Gray Katherine R.,
Royle Natalie,
Wolz Robin,
Hill Derek L.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.110
Subject(s) - segmentation , artificial intelligence , fluid attenuated inversion recovery , pattern recognition (psychology) , hyperintensity , prior probability , computer science , bayesian probability , magnetic resonance imaging , medicine , radiology
based analysis for group differences using two-sided t-tests was performed in SPM5. Results:Women who had hypertension later in life had smaller total gray matter volumes than the women who did not have late-life hypertension (p1⁄40.03). This difference was localized in the occipital lobes with some involvement of the precuneus on voxel-based analysis (p<0.001; uncorrected for multiple comparisons) (Figure). Conclusions: Previous neuroimaging studies of women at the time of eclamptic pregnancies demonstrated vasogenic edema involving the posterior circulation. In a fraction of these patients neuroimaging abnormalities persist up to 6 weeks postpartum, presumably caused by gliosis. However, long-term follow-up of these women is not available. Our results indicate that in women with histories of preeclampsia, those who have hypertension later in life demonstrate structural changes in the occipital lobe that are not seen in women who did not have late-life hypertension. The long-term effects of these brain structural changes on cognitive function need to be investigated.