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P1‐344: Poor Sleep Quality is Associated with CSF Markers of Amyloid Deposition in Cognitively Healthy Adults at Risk for Alzheimer's Disease
Author(s) -
Sprecher Kate E.,
Zetterberg Henrik,
Blennow Kaj,
Carlsson Cynthia M.,
Okonkwo Ozioma C.,
Sager Mark A.,
Asthana Sanjay,
Johnson Sterling C.,
Bendlin Barbara B.,
Benca Ruth M.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1095
Subject(s) - sleep (system call) , polysomnography , medicine , alzheimer's disease , disease , asymptomatic , apnea , computer science , operating system
ques (.868) and CAA (.362) were associated on an “AD pathology” factor, while large infarcts (.368), microinfarcts (.444), atherosclerotic vascular pathology (.352) and arteriosclerosis (.568) loaded on a second, “Vascular pathology” factor. Hippocampal sclerosis was not significantly associated with either Factor 1 (-.098) or Factor 2 (.056). At all time points, individuals with factor loadings >.4 on the AD pathology factor were more severely impaired on all cognitive measures than those with loadings <.4. Individuals with strong loadings on the Vascular pathology factor were cognitively similar to those with weak loadings on both factors. Results from regression models showed that memory performance was the most consistent predictor of AD factor loadings. None of the cognitive measures predicted Vascular factor loadings. Conclusions: Our results suggest that different pathologies tend to co-occur predictably in the brains of demented individuals, and that AD pathology appears to contribute more strongly than vascular pathology to in vivo cognitive impairment.