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P1‐338: Assessing Risk for Preclinical β‐Amyloid Pathology with APOE , Cognitive and Demographic Information
Author(s) -
Insel Philip S.,
Palmqvist Sebastian,
Mackin Scott,
Nosheny Rachel L.,
Gessert Devon,
Hansson Oskar,
Weiner Michael W.,
Mattsson Niklas
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1089
Subject(s) - neuropsychology , apolipoprotein e , medicine , neuroimaging , alzheimer's disease neuroimaging initiative , demographics , disease , biomarker , observational study , cohort , cognition , pathology , cognitive decline , clinical trial , oncology , cognitive impairment , dementia , psychiatry , demography , biochemistry , chemistry , sociology
have higher dementia prevalence, different genetic markers and higher vascular risk factors. However, pathological underpinnings are unknown. Methods:We included 111 AA demented autopsies and 444 random Caucasians autopsies and compared the two groups regarding demographics, cognition, apolipoprotein E (ApoE), comorbidities including cerebrovascular pathology and Lewy body disease (LBD), clinical and pathological diagnoses, neuropathological Alzheimer disease (AD) criteria, quantitative Ab and tau scales, neuropathological vascular findings and nonAlzheimer diseases. Results:When comparing AA and Caucasians the primary clinical diagnoses differed but the primary pathological diagnoses did not. Importantly, there is evidence that AA had more AD-related pathology, measured as meeting the NIA/Reagan and CERAD criteria and throughAD neuropathological features (Braak Stage, CERAD neuritic and diffuse plaque scores). ApoE 4 was more common in AA than Caucasians. There were significant differences vascular, LBD and TDP pathology. Conclusions: Primary pathological diagnosis does not differ between groups however AD, LBD and vascular pathology are more common in AA and TDP and Tau less common. ApoE accounts for most of the AD pathology scales differences. These similarities and differences are important in public policy.