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P1‐333: Focused Ultrasound‐Mediated Delivery of Natural Antibodies to The Brain Facilitates Neuronal Plasticity in an Amyloidosis Mouse Model
Author(s) -
Dubey Sonam,
Burgess Alison,
McLaurin JoAnne,
Branch Donald R.,
Hynynen Kullervo,
Aubert Isabelle
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1084
Subject(s) - medicine , amyloidosis , neurogenesis , immunohistochemistry , pathology , antibody , genetically modified mouse , cognitive decline , amyloid (mycology) , disease , transgene , immunology , neuroscience , biology , dementia , biochemistry , gene
any significant effects. There were no significant effects of gender or the interaction of ethnicity and gender on any analyte. Conclusions:Ab42 is more associated with disease states, including AD, and is the more amyloidogenic form. S100B is expressed by astrocytes and increased levels in CSF have been described in mild-moderate AD. Serum S100B levels are thought to be a peripheral biomarker of blood-brain-barrier permeability or CNS injury. Overall, these preliminary results provide support for increased neurodegeneration in AAwith AD. The mechanistic implications of these levels will require further research. Our future studies include measurement of inflammatory proteins in this brain region as well as investigation of potential mechanisms, including potential ethnicity-related SNP differences in specific genes.