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P1‐329: Age‐Related Topological Disruption of The White Matter Structural Network in Amnestic Mild Cognitive Impairment
Author(s) -
Sheng Can,
Zhao Da Teng,
Shu Ni,
Han Ying
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1080
Subject(s) - precuneus , cuneus , white matter , connectome , tractography , diffusion mri , parahippocampal gyrus , neuroscience , human connectome project , grey matter , lingual gyrus , psychology , medicine , cognition , temporal lobe , functional connectivity , magnetic resonance imaging , epilepsy , radiology
thickness by months 24 (p<.001) and 36 (p1⁄4.003). For CN, no associations were noted for hippocampus and entorhinal cortex. However, higher IR predicted less MTL CT across time (p<.001). Conclusions: Similar to previous work, we found that higher baseline IR was moderately related to brain atrophy over time. This pattern for both MCI and AD is comparable to what is seen for glucose metabolism in this cohort. IR may be a useful biomarker for AD neuropathology.