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IC‐P‐079: Neuropsychological and Gray Matter Volume Decline in Presymptomatic C9ORF72 Mutation Carriers
Author(s) -
Jiskoot Lize C.,
Rombouts Serge A.R.B.,
Panman Jessica L.,
Dopper Elise G.P.,
Heijer Tom den,
Franzen Sanne,
Pijnenburg Yolande A.L.,
Minkelen Rick,
Swieten John C.,
Papma Janne M.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.108
Subject(s) - c9orf72 , white matter , neuropsychology , gray (unit) , psychology , magnetic resonance imaging , medicine , grey matter , audiology , nuclear medicine , psychiatry , disease , frontotemporal dementia , radiology , dementia , cognition
(p1⁄40.78) was there an association between volume and microinfarct presence. In contrast there was an association between greater NFT density and smaller hippocampal volume (p1⁄40.04), though (because of low NFT burden), there was no association in MFG between NFT and smaller volumes (p1⁄40.23). Conclusions: In these patients, the microinfarcts most commonly occurred in a cortical watershed zone (MFG) as well as in the posterior hippocampus. We also confirmed the established association between increased NFT pathology and smaller hippocampal volumes, but the effects of microinfarcts on macroscopic measures of gray matter volume were not statistically significant.