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P1‐328: Insulin Resistance and Longitudinal Associations with Temporal Atrophy Across The Alzheimer's Disease Spectrum
Author(s) -
Klinedinst Brandon Skylar,
Webb Joseph L.,
Cerna Jonathan,
Willette Auriel A.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1079
Subject(s) - atrophy , entorhinal cortex , temporal lobe , neuroimaging , hippocampus , alzheimer's disease neuroimaging initiative , temporal cortex , alzheimer's disease , psychology , medicine , cardiology , neuroscience , audiology , disease , epilepsy
aration between GM and CBFmarkers. Within modalities some positional variance existed, especially within the GM markers where the Gaussian fit was not robust over cross-validation samples. Conclusions:This EBM analysis suggests that ASL-MRI-based perfusion changes occur later in the AD disease course than GM volume changes. We should be careful in generalizing these findings which might arise from ASL-MRI being less sensitive than T1-weighted MRI. Our findings therefore only hold for the current regional measures, cohort, and ASL-MRI technique. Our future work concerns evaluation of other potentially more sensitive ASL-MRI-based markers.