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P1‐321: White Matter Microstructure Disruption Could Be an Early Phenomenon in The Pathophysiology of Preclinical Alzheimer's Disease: FundaciÓ ACE Healthy Brain Initiative
Author(s) -
Rodriguez-Gomez Octavio,
Sanabria Angela,
Perez Alba,
Sanchez Domingo,
Ruiz Susana,
Tarragona Marina,
Pavía Javier,
Campos Francisco,
Vivas Assumpta,
Chiari Marta Gómez,
Tejero Miguel Angel,
Alegret Monserrat,
Espinosa Ana,
Ortega Gemma,
Abdelnour Carla,
Hernandez Isabel,
Ruiz Agustin,
Giménez Joan,
Lomeña Francisco,
Tarraga Lluis,
Sotolongo-Grau Oscar,
Boada Mercè
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1072
Subject(s) - white matter , diffusion mri , psychology , pathophysiology , population , cardiology , neuroscience , medicine , magnetic resonance imaging , radiology , environmental health
analysis. Searches were conducted through PubMed and Google Scholar. Only English papers that contained search terms in title and/or abstract: AD or MCI, and MRI, and grey matter, whole brain, cortical thickness, hippocampus, medial temporal lobe were taken into account. In total, 1930 articles were found. Reviews (n1⁄4138), case reports (n1⁄47), papers about animal models (n1⁄499), medication trails (n1⁄445), autopsy-based studies (n1⁄442), articles that compared AD with other dementias (n1⁄4174), and articles that not fulfilled the criteria (n1⁄41053) were deselected. Of the remaining 372 articles, 252 described cross-sectional studies based on structural MRI in patients within the AD spectrum and/or controls, 120 described studies based on a volumetric MRI technique. Results:Further analyses, including evidence based grading of the selected 372 papers are planned in the first quartile of 2016. Conclusions:This systematic review gives an overview of methodological developments that allow volumetric assessment of different brain regions in vivo, and summarize the results of structural imaging studies covering the entire AD spectrum as compared to healthy ageing.