Premium
P1‐319: The Effect of Gray Matter Volume and Amyloid Load on Normal Cognitive Performance in Cognitively Intact Older Adults
Author(s) -
Evenepoel Charlotte,
Schaeverbeke Jolien,
Adamczuk Katarzyna,
Nelissen Natalie,
Van Laere Koen,
Dupont Patrick,
Vandenberghe Rik
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1070
Subject(s) - voxel , psychology , neuropsychology , population , audiology , effects of sleep deprivation on cognitive performance , dementia , cognition , medicine , nuclear medicine , neuroscience , radiology , environmental health , disease
a model in which tau pathology precedes neurodegeneration. The widespread extent of elevated AV-1451 suggests the presence of tau pathology throughout cortex in AD patients, whereas hypometabolism wasmore constrained to temporoparietal regions with especially high AV-1451 uptake. These regions may be vulnerable to early development or converging spread of tau pathology across the AD clinical spectrum.