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IC‐P‐077: Relationship of Family History of Alzheimer’s Disease and APOE Genotype with Cerebral Amyloid Deposition and Glucose Metabolism in Cognitively Normal Middle‐ and Old‐Aged Adults
Author(s) -
Lee Younghwa,
Yi Dahyun,
Byun Min Soo,
Choe Young Min,
Choi Hyo Jung,
Baek Hyewon,
Lee Jun Ho,
Kim Hyun Jung,
Ko Hyunwoong,
Sohn Bo Kyung,
Lee Jun-Young,
Jung Jung Gi,
Sohn Chul-Ho,
Kim Yu Kyeong,
Woo Jong Inn,
Lee Dong Young
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.106
Subject(s) - apolipoprotein e , precuneus , medicine , family history , psychology , alzheimer's disease , endocrinology , pittsburgh compound b , disease , neuroscience , cognition
IC-P-077 RELATIONSHIP OF FAMILY HISTORY OF ALZHEIMER’S DISEASE AND APOE GENOTYPE WITH CEREBRAL AMYLOID DEPOSITION AND GLUCOSE METABOLISM IN COGNITIVELY NORMAL MIDDLEAND OLD-AGED ADULTS Younghwa Lee, Dahyun Yi, Min Soo Byun, Young Min Choe, Hyo Jung Choi, Hyewon Baek, Jun Ho Lee, Hyun Jung Kim, Hyunwoong Ko, Bo Kyung Sohn, Jun-Young Lee, Jung Gi Jung, ChulHo Sohn, Yu Kyeong Kim, Jong Inn Woo, Dong Young Lee, Seoul National University Hospital, Seoul, The Republic of Korea; 2 Medical Research Center Seoul National University, Seoul, The Republic of Korea; Ulsan University Hospital, Ulsan, The Republic of Korea; SMG-SNU Boramae Medical Center, Seoul, The Republic of Korea; 5 SNU Hospital Boramae, Seoul, South Korea. Contact e-mail: marialee0722@gmail.com Background: Family history (FH) of Alzheimer’s disease, as well as apolipoprotein-E (APOE) ε4, is well-recognized risk factor for developing AD. However, the relationship between FH of AD and AD-related brain alterations in cognitively normal adults is still poorly known. We examined the association of family history of ADwith beta-amyloid deposition and glucose metabolism in cognitively normal adults, controlling the influence of APOE genotype. We also investigated the association of APOE genotype on brain changes controlling the effect of FH. Methods:This study included 153 healthy cognitively normal middleand old-aged adults, who participated in the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s disease (KBASE), an ongoing prospective cohort study. Among the subjects, 29 had positive family history of AD (FH+). FH+ was defined as having at least 1 first-degree member (i.e., parent or sibling) with AD. All participants underwent comprehensive clinical and neuropsychological assessment, MRI, C-Pittsburgh compound B (PiB)-PET and FFDG-PET Scans. SPM12 was used to obtain cerebral-to-cerebellar PiB and FDG SUVR across groups. The group effects were tested with a 2 x 2 ANCOVA factorial design (FH+/FHand APOE4+/ APOE4-, covariate: age). Results: FH+ group showed significantly higher PiB retention in the frontal, lateral-temporal cortex and global cortical region, but no differences of glucose metabolism in any cortical region compared to those without FH (FH-) even when the effect of APOE ε4 was controlled. APOE ε4 carriers (APOE4+) had decreased glucose metabolism in the precuneus, angular gyrus and medial-frontal cortex, but no differences of PiB retention, compared to non-carriers (APOE4-) when the effect of FH was controlled. Conclusions:Our study demonstrated that while APOE ε4 genotype is related to hypometabolism and atrophy in the AD-related anatomic regions, FH ofAD is associatedwith increased cerebral amyloid deposition when controlling each other. The findings suggest that FH of AD and APOE genotype may differentially influence on AD process through stage-specific ways.