P1‐302: Sex Hormone Levels Moderate The Effects of Alzheimer's Disease on Subcortical Morphometry | Zendy

Gutman Boris A. | Zendy; Riedel Brandalyn | Zendy; Ragothaman Anjani | Zendy; Thompson Paul M. | Zendy

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P1‐302: Sex Hormone Levels Moderate The Effects of Alzheimer's Disease on Subcortical Morphometry

Author(s) -

Gutman Boris A.,

Riedel Brandalyn,

Ragothaman Anjani,

Thompson Paul M.

Publication year - 2016

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2016.06.1052

Subject(s) - medicine , putamen , atrophy , endocrinology , testosterone (patch) , sex hormone binding globulin , psychology , amygdala , luteinizing hormone , brain morphometry , neurodegeneration , hormone , androgen , disease , magnetic resonance imaging , radiology

training, 1,2, or 3 times per week, and for 6 or 12 months. Exercise adherence was calculated as the percentage of exercise classes attended during the exercise-training period. Robust mixed-model regression, including study as a random effect, determined whether baseline lPFC volume predicted exercise adherence. Results:Across the three studies, average exercise adherence was 66% (range 0%100%) and average baseline lPFC volume was 68.2cm (range 43cm-86cm). Independent of baseline intracranial volume, age, and treatment condition, larger lPFC volume predicted greater exercise adherence, such that each 1cm increase in lPFC volumewas associated with a 0.6-percentage point increase in exercise adherence (95%CI: 0.1-1.1). Regional analysis showed that this relationship was driven by volume in the middle frontal gyrus (0.9, 95%

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