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P1‐300: Cost Effective AB Enrichment Strategies for Recruiting a Preclinical Cohort
Author(s) -
Salvado Olivier,
Fowler Christopher,
Masters Colin L.,
Ames David,
Martins Ralph N.,
Villemagne Victor L.,
Rowe Christopher C.,
Burnham Samantha
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1050
Subject(s) - cohort , medicine , asymptomatic , false positive paradox , nuclear medicine , artificial intelligence , computer science
pants from the AIBL Study with C-PiB PET imaging at 18-monthly intervals over six years. Only participants with three or more PET assessments were included in analysis. Linear mixed models regression was performed for Ab SUVR (dependent variable) and Baseline Hypertension Status, Antihypertensive Treatment, Time (and their twoand three-way interactions), as well as age, gender, education, APOE ε4, cholesterol, glucose, smoking and BMI. Results: Age, APOE ε4, Gender, Time, and APOE ε4 x Time were all associated with longitudinal measures of Ab burden. There was also a significant three-way interaction (Hypertensive x Antihypertensive Treatment x Time, p 1⁄4 0.02), such that participants with untreated high blood pressure at baseline had greatest increases in Ab over time. Findings remained significant after adjustment for BMI, cholesterol, glucose and smoking. Conclusions: In hypertensive cognitivelynormal controls, use of antihypertensive medication was associated with less Ab accumulation over time compared with their untreated peers. Although observational only, this study provides some in vivo biomarker evidence supporting that lifestyle risk factor modification may mitigate the pathology of AD.