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IC‐P‐074: Genome‐Wide Meta‐Analysis of Transcriptome Profiling Identifies Novel Dysregulated Genes Implicated in Alzheimer’s Disease
Author(s) -
Nho Kwangsik,
Kim Sungeun,
Risacher Shan L.,
Apostolova Liana G.,
Lin Kuang,
Keohane Aoife,
Lun Katie,
Hodges Angela,
Allen Mariet,
Wang Xue,
Burgess Jeremy D.,
Ertekin-Taner Nilufer,
Petersen Ronald C.,
Soares Holly,
Singh Parul,
Wang Lisu,
Qi Zhenhao,
He Aiqing,
Neuhaus Isaac,
Patel Vishal,
Foroud Tatiana M.,
Faber Kelley,
Lovestone Simon,
Simmons Andrew,
Weiner Michael W.,
Saykin Andrew J.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.104
Subject(s) - transcriptome , microarray analysis techniques , microarray , gene expression profiling , biology , gene , gene expression , multiple comparisons problem , false discovery rate , fold change , bonferroni correction , meta analysis , genetics , computational biology , medicine , pathology , statistics , mathematics
(Fig. 1). Individuals with lower expression showed greater cortical thickness (corrected p<0.05). Higher ABCA7 expression was also associated with decreased metabolic activity ([F] FDG PET) in Hippocampus (p1⁄40.033; Fig. 2). cis-eQTL mapping analyses of ABCA7 detected 63 significant associations with p < 2.5x10 (Fig. 3). The most significant cis-eQTL SNP (rs5638817) was replicated (Fig. 2) and was significantly associated with increased metabolic activity ([F] FDG PET) in Hippocampus (p<0.05) (Fig. 4). Conclusions:This is the first study to show that LOAD susceptibility gene ABCA7 expression in blood is associated with decreased cortical thickness and reduced metabolic activity in AD-related brain regions and CD33 expression is associated with decreased cortical thickness.