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P1‐278: Cortical Cerebral Microinfarcts on 3 Tesla Magnetic Resonance Imaging: A Novel Marker of Cerebrovascular Disease
Author(s) -
Hilal Saima,
Sikking Emiel,
Amin Shaik Mohammad,
Veluwe Susanne,
Vrooman Henri,
Cheung Carol Y.,
Wong Tien Yin,
Venketasubramanian Narayanaswamy,
Biessels Geert Jan,
Chen Christopher,
Ikram Mohammad Kamran
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1028
Subject(s) - dementia , medicine , hyperintensity , cardiology , magnetic resonance imaging , odds ratio , stroke (engine) , lacunar stroke , population , cognitive decline , disease , radiology , ischemic stroke , ischemia , mechanical engineering , engineering , environmental health
compared to younger ones. Methods: In six younger (2362.1 years of age, three women) and six older (68.867.6 years, three women) healthy subjects we measured dynamic [F]AV-1451 uptake over a three-hour period. In the same subjects we obtained dynamic gadolinium concentrations before and after a bolus injection of gadolinium, a large molecule commonly used to assess the permeability of the blood-brain barrier, by performing a pre-contrast 3D T1 map (five flip angle acquisitions) followed by a dynamic contrast enhanced MRI (DCEMRI). During and after infusion, we acquired 180 consecutive T1-weighted volumes (3.4 sec per volume) over 10 minutes. Non-displaceable binding potential (BPND) of [ F]AV-1451 and permeability parameters (Ktrans) of gadolinium were analyzed by volume-of-interest methods and compared using Spearman’s correlation coefficients. Results: There was greater BPND of [ F]AV-1451 in the globus pallidus and putamen (but not in cerebellum or cerebral cortex) of older as compared to younger subjects. Gadolinium Ktrans was similar in the cerebellum, temporal cortex, and choroid plexus of younger and older subjects, but there was higher permeability in the substantia nigra, globus pallidus, and putamen (all p<0.05) of older as compared to younger subjects. Correlations between BPND and Ktrans were significant for substantia nigra, globus pallidus and putamen (all p<0.05). Conclusions: Increased capillary permeability in substantia nigra, pallidum and putamen of healthy older subjects could underlie some of the regional differences in [F]AV-1451 uptake observed in older as compared to younger healthy subjects.