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IC‐P‐071: Longevity Gene Klotho Alters Apoe4‐Related Cortical Thinning: Findings from The Wisconsin Registry for Alzheimer’s Prevention
Author(s) -
Schultz Stephanie A.,
Boots Elizabeth A.,
Oh Jennifer M.,
Darst Burcu F.,
Koscik Rebecca L.,
Gallagher Catherine L.,
Carlsson Cynthia M.,
Rowley Howard A.,
Bendlin Barbara B.,
Asthana Sanjay,
Sager Mark A.,
Hogan Kirk J.,
Hermann Bruce P.,
Engelman Corinne D.,
Johnson Sterling C.,
Dubal Dena B.,
Okonkwo Ozioma C.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.101
Subject(s) - heterozygote advantage , apolipoprotein e , klotho , allele , entorhinal cortex , medicine , alzheimer's disease neuroimaging initiative , dementia , oncology , disease , biology , hippocampal formation , genetics , gene , kidney
selected 9 mRNA transcripts and sex with an accuracy of 83.5% and an AUC1⁄40.84. The addition of ApoE4 genotype, which has been shown to be strongly associated with brain amyloidosis, did not result in significant improvement of the classifier’s accuracy and AUC (accuracy1⁄484.7%, AUC1⁄40.87) (Figure 1E-F). Conclusions:Automated multimodal biomarker classifiers using cognitive measures and peripheral mRNA levels show promise for predicting MCI conversion and brain amyloidosis. Identification of abnormalities in peripheral blood might lead to noninvasive tests for presymptomatic AD diagnosis.