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IC‐P‐064: Regional Association Between Cortical Volumes and Imaging TAU Pathology Using 18 F‐AV1451 and 18 F‐THK5351
Author(s) -
Dore Vincent,
Bourgeat Pierrick,
Fripp Jurgen,
Macaulay S Lance,
Masters Colin L.,
Ames David,
Martins Ralph N.,
Salvado Olivier,
Rowe Christopher C.,
Villemagne Victor L.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.094
Subject(s) - nuclear medicine , neocortex , pons , cortex (anatomy) , tau pathology , chemistry , alzheimer's disease , pathology , medicine , neuroscience , psychology , anatomy , disease
mild cognitive impairment (MCI) patients from the ADNI, (2) 194 clinically normal (CN) older participants from the ADNI (age 60 to 90), and (3) 1322 CN younger participants from the Brain Genomics Superstruct Project (age 18 to 35). Results:Within MCI and older CN, elevated PGRS was associated with smaller hippocampus volume and greater cognitive decline. PGRS was also associated with hippocampus volume within young CN. This pattern was evident when examining the liberal PGRS, but not the conservative PGRS. All effects were independent of age and APOE4 status. Conclusions:An impact of common genetic risk loci distributed throughout the genome is detectable in younger and older nondemented individuals. The influence of this genetic risk may begin in early life and make an individual more susceptible to cognitive impairment in late life. Future refinement of polygenic risk scores may help identify individuals at risk for AD dementia.