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IC‐P‐058: Parietal White Matter Hyperintensity Predominate APOE‐E4 Related Information Processing Speed Decline in Cognitively Intact Elderly: A Structural MRI Study
Author(s) -
Luo Xiao',
Jiaerken Yerfan,
Qiu Tiantian,
Huang Peiyu,
Jia Yunlu,
Zhang Minming
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.088
Subject(s) - apolipoprotein e , white matter , hyperintensity , parietal lobe , grey matter , psychology , audiology , medicine , analysis of variance , cardiology , magnetic resonance imaging , neuroscience , disease , radiology
sults: The first classifier achieved an accuracy of 84.6% (AUC1⁄40.85) using only Cathepsin D and Ab1-42 (Figure). The addition of APOE4 did not improve classifier accuracy (accuracy1⁄484.7%, AUC1⁄40.81). The best predictors in this model were APOE4, gender, and NRGN as predictors (Figure). Conclusions: NDE proteins show promise for the prediction of amyloid pathology and the potential to increase diagnostic certainty by identifying underlying AD pathology in both clinical care and clinical trials. APOE4 failed to improve diagnostic accuracy indicating that NDE measurements alone provide sufficient information for accurate prediction.