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IC‐P‐056: Sleep Disordered Breathing, CSF P‐TAU, Hippocampal Atrophy and B‐Amyloid Deposition in Mild Cognitive Impairment Patients
Author(s) -
Bubu Omonigho Michael,
Mortimer James,
Schwartz Skai,
Morgan David,
Anderson William,
Wu Yougui,
Borenstein Amy
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.086
Subject(s) - alzheimer's disease neuroimaging initiative , atrophy , neuroimaging , medicine , dementia , cohort , cerebrospinal fluid , oncology , confidence interval , cognitive decline , psychology , cardiology , neuroscience , disease
cerebellum reference) to generate Centiloids. The relationship between Centiloids versus CERAD and Thal stages was investigated. Finally, we assessed the performance of two a priori thresholds previously introduced by our group (liberal –SUVR 1.21 1⁄4 7.47 Centiloids; conservative –SUVR 1.40 1⁄4 27.48 Centiloids), and further derived an empirical threshold by performing ROC analysis of the current dataset, using CERAD moderate-frequent plaques as the standard of truth. Results: CERAD none-sparse patients had a mean of -4.8566.88 Centiloids; the moderate-frequent group had 66.02650.45 Centiloids (t-test, p<0.001). The ROC analysis identified 9.50 Centiloids as the optimal threshold with 0.89 sensitivity (95% CI:0.71-0.97), 1.00 specificity (0.86 – 1.00); AUC 0.91 (0.808-1.000) (Figure 1). The a priori liberal threshold had identical sensitivity and specificity as the ROC-derived threshold. These thresholds also distinguished between Thal phases 0-2 and 3-5 (Figure 2). The a priori conservative threshold had sensitivity of 0.68 (0.48-0.83) and specificity of 1.00 (0.86-1.0). Conclusions: The a priori liberal threshold (7.47 Centiloids) and the ROCderived threshold (9.50 Centiloids) showed excellent sensitivity/ specificity, and could be considered for detection of early amyloid signal. By the time of AAIC we anticipate processing at least 100 additional cases currently being provided by multiple sites in order to validate these preliminary results.