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IC‐P‐055: Centiloid Thresholds for Amyloid Positivity Derived from Autopsy‐Proven Cases
Author(s) -
Ayakta Nagehan,
Seeley William W.,
Grinberg Lea T.,
Lockhart Samuel N.,
O'Neil James P.,
Ossenkoppele Rik,
Reed Bruce,
Olichney John,
Boxer Adam L.,
Miller Bruce,
Borys Ewa,
Jin Lee-Way,
Huang Eric,
DeCarli Charles,
Jagust William J.,
Rabinovici Gil D.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.085
Subject(s) - autopsy , medicine , nuclear medicine , dementia , pathology , disease
of 2.7 years (See Table 1 for details). Significant relationships existed between higher global PHFtau tangle burden and inward surface deformity in CA1 and CA2-4+GD (Figure 1), between higher b-amyloid load and inward subiculum deformity (trend, Figure 2), with differing patterns along the hippocampal surface. No significant relationship between surface shape and TDP-43 pathology was observed. Conclusions:PHFtau tangles and b-amyloid AD pathology burdens were related to specific regional hippocampal surface deformity, with differing patterns on the surface. We did not find associations between TDP-43 inclusions and surface deformity. These findings provide support that specific patterns of hippocampal atrophy may be biomarkers for specific AD pathologies. These results need to be further validated in larger samples.