Premium
IC‐P‐054: Ante‐Mortem Structural MRI Markers for Post‐Mortem Pathology for TDP‐43 and Ad in The Hippocampus
Author(s) -
Hanko Veronika,
Alpert Kathryn I.,
Schneider Julie A.,
Arfanakis Konstantinos,
Bennett David A.,
Wang Lei
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.084
Subject(s) - dementia , subiculum , hippocampal formation , hippocampus , atrophy , neuroimaging , neuroscience , pathology , autopsy , alzheimer's disease , neuropathology , medicine , psychology , disease , dentate gyrus
elderly, 203 mild cognitive impairment (MCI), and 95 mild AD dementia subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Subjects underwent clinical assessments for apathy using the neuropsychiatric inventory questionnaire (NPI-Q) at baseline and over three years. We employed backward elimination general linear and mixed effects models to evaluate the relationship between baseline FDG metabolism in five regions implicated in the neurobiology of apathy and AD (orbitofrontal, anterior cingulate, inferior temporal, posterior cingulate, and supramarginal cortices) versus baseline and longitudinal apathy. Covariates included age, gender, diagnosis, apolipoprotein E genotype, premorbid intelligence, cognition, and antidepressant use. Results:Cross-sectional analysis revealed that posterior cingulate gyrus hypometabolism (p1⁄40.035; partial regression coefficient (B)1⁄4-0.63, 95% CI1⁄4-1.22, -0.04), diagnosis (p<0.0001; adjusted mean for AD>MCI>CN), male sex (p1⁄40.025), and antidepressant medication use (p1⁄40.034) were significantly associated with greater apathy at baseline. Longitudinal analysis revealed that the interaction of surpamarginal hypometabolism and time (p1⁄40.01; reduction of slope across time by -0.6 per unit hypometabolism, 95% CI1⁄4-1.05,-0.13), posterior cingulate gyrus hypometabolism (p1⁄40.013; B1⁄4-0.66, 95% CI1⁄4-1.18, -0.14), diagnosis (p<0.0001; adjusted mean for AD>MCI>CN), male sex (p1⁄40.031), and antidepressant medication use (p1⁄40.019) were significantly associated with greater apathy across time; only supramarginal hypometabolism was related to greater rate of increase of apathy. Conclusions: These results support an association of apathy with hypometabolism in regions commonly affected in AD pathogenesis and/or a localization of this NPS in AD to medial and lateral parietal brain regions, rather than those typically implicated in the neurobiology of apathy. Future work is needed to differentiate between these alternatives and to investigate the association of apathy with common AD proteinopathies.