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IC‐02‐05: Cerebrospinal Fluid Strem2 Levels are Associated with Gray Matter Volume Increases and Reduced Diffusivity in Early Alzheimer’s Disease
Author(s) -
Gispert Juan D.,
Suarez-Calvet Marc,
Monte Gemma C.,
Tucholka Alan,
Falcon Carles,
Rojas Santiago,
Rami Lorena,
Sanchez-Valle Raquel,
Llado Albert,
Kleinberger Gernot,
Haass Christian,
Molinuevo Jose Luis
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.070
Subject(s) - cerebrospinal fluid , fractional anisotropy , precuneus , medicine , pathology , diffusion mri , neuroscience , psychology , chemistry , endocrinology , magnetic resonance imaging , cognition , radiology
superior frontal cortices and temporal pole, were on average .57. Left and right hemisphere showed similar correlations. Correlations assessed in randomly paired subjects were lower ( < .2) and not significant. Conclusions:Cortical thickness correlates between MZ twins. These data suggest that in addition to a strong genetic background for cortical thickness in cognitively healthy elderly also non-genetic factors substantially influence this AD-biomarker. Future studies on the causes of identical twin discordance may provide novel insights into the pathophysiology of AD which may provide clues for AD prevention.