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IC‐01‐04: 18 F‐AV1451 Pet Detects TAU Pathology in MAPT Mutation Carriers and Correlates Strongly with Immunohistochemistry of TAU Aggregates
Author(s) -
Smith Ruben,
Puschmann Andreas,
Olsson Tomas,
Englund Elisabet,
Hansson Oskar
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.064
Subject(s) - neuropathology , atrophy , pathology , temporal lobe , tau protein , medicine , hippocampus , psychology , alzheimer's disease , neuroscience , disease , epilepsy
Background: The Tau PET ligand F-AV1451 has been shown to reliably detect paired helical filaments of tau in Alzheimer’s disease, but it is not yet known whether it binds to the tau aggregates present in patients with mutations in the gene (MAPT) coding for the tau protein. Further, no study has yet compared the cerebral retention of F -AV1451 with the tau aggregates revealed using neuropathology. Methods: Three patients from a Swedish family carrying the R406W mutation of MAPTwere assessed with cognitive tests and subjects underwent F-AV1451 and F-Flutemetamol PET scans. Further one of younger subjects also underwent an F-FDG PET scan. The oldest subject died two weeks after the scan and the brain was processed for neuropathology. Tau immunohistochemistry was performed on brain sections from affected and unaffected brain regions. Results: Two mutation carriers, aged 56 and 60 years, had disease durations of 5-10 years and still only exhibited mild-moderate episodic memory impairment and no clear behavioural deficits. The MRI revealed only slight cortical atrophy and F-AV1451 PET imaging showed uptake in the hippocampus and the temporal lobes, especially in the inferior and anterior parts (Fig 1A, B). The uptake of F -AV1451 correlated well with hypometabolism revealed with FGD PET in one of the subjects. The third case, 76 years, had a disease duration of >20 years and exhibited clear cognitive impairment, behavioural disturbances, mutism and dysphagia. The CT Figure 2c. Relationship between mean AV-1451 SUVR and attentional control