Premium
IC‐P‐043: Neuroimaging Correlates of Anosognosia in Mild Cognitive Impairment
Author(s) -
Vannini Patrizia,
Hanseeuw Bernard J.,
Munro Catherine E.,
Amariglio Rebecca,
Marshall Gad A.,
Rentz Dorene M.,
Pascual-Leone Alvaro,
Johnson Keith,
Sperling Reisa A.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.053
Subject(s) - anosognosia , psychology , resting state fmri , orbitofrontal cortex , neuroimaging , posterior cingulate , neuroscience , dementia , anterior cingulate cortex , cognition , audiology , medicine , disease , prefrontal cortex
averaged across voxels. Using voxel-based regression, we tested whether in MCI subjects higher education was associated with stronger FDG-PET hypometabolism, controlling for memory performance. In further regression analyses, we tested whether higher global LPFC connectivity was associated with higher education and reduced effects of FDG-PET hypometabolism onto episodic memory (interaction FDG-PET metabolism x global LPFC connectivity). Results: Higher education was associated with stronger precuneus FDG-PET hypometabolism in MCI-Ab+ but not MCIAbsubjects, when controlling for composite memory scores. This suggests that MCI-Ab+ with higher CR can better cope with FDG-PET hypometabolism. In the MCI-Ab+ subjects, higher education was associated with higher global LPFC connectivity. The interaction global LPFC connectivity x precuneus FDG-PET was significant in MCI-Ab+ subjects (p<0.05), such that at higher levels of LPFC global connectivity the association between precuneus FDG-PET hypometabolism and memory impairment was attenuated, suggesting compensatory effects of the LPFC (see Fig. 1). Conclusions: Higher global LPFC connectivity may contribute to higher CR and compensate FDG-PET hypometabolism in prodromal AD, thus allowing to maintain memory performance relatively well.