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IC‐P‐028: Sleep Quality in Young and Middle Age‐Period is Associated With Cerebral Amyloid Burden in Cognitively Normal Elderly People
Author(s) -
Choe Young Min,
Byun Min Soo,
Yi Dahyun,
Choi Hyo Jung,
Baek Hyewon,
Lee Jun Ho,
Kim Hyun Jung,
Sohn Bo Kyung,
Kim Jee Wook,
Lee Younghwa,
Ko Hyunwoong,
Han Na Young,
Lee Seung Hoon,
Ko Kang,
Woo Jong Inn,
Lee Dong Young
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.038
Subject(s) - pittsburgh sleep quality index , precuneus , posterior cingulate , medicine , sleep (system call) , psychology , cardiology , cognition , sleep quality , psychiatry , computer science , operating system
trate the regions of significance. Results:The association between baseline levels of cognition and inflammation was greater in the Tg than Wt rats in the right nucleus accumbens, whereas in the opposite was seen in the right inferior colliculus. The association between baseline levels of inflammation and change in cognition at follow-up, several regions including the left retrosplenial cortex, right hippocampus, and the right posterior commissure showed higher decrease in cognition of the Tg animals compared to the Wt (Figure 1). Conclusions:At baseline, there is no association between neuroinflammation and cognitive performance; however in more aged rats, baseline levels of PBR is able to predict cognitive decline. The results provide a framework that could potentially be applied in human studies focusing on the detrimental roles of neuroinflammation in AD.