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IC‐P‐021: Impact of 18 F‐ Florbetapir Pet‐CT on Clinical Diagnosis and Management of Patients With Possible Alzheimer’s Disease
Author(s) -
Raczek Malgorzata,
Dizdarevic Sabina,
Singh Kalpana,
Tabet Naji,
Abraham Rajesh,
Fowler J Charlotte,
Ridha Basil H.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.031
Subject(s) - medicine , medical diagnosis , dementia , referral , retrospective cohort study , disease , radiology , family medicine
tein (Ab) deposition. In this study, we investigated the association between sex hormones and cerebral Ab deposition in cognitively normal elderly population. Methods: Through the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE), 117 cognitively normal elderly subjects (female 61, male 56) were included in this study. All the subjects underwent comprehensive clinical and neuropsychological assessment, 11Clabelled Pittsburgh Compound B (PiB) positron emission tomography (PET), and blood sampling. Global cerebral Ab deposition was defined as mean cortical PiB retention of the cortical regions including the frontal, lateral temporal, lateral parietal and precuneus/posterior cingulate cortices. Plasma estradiol, testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and sex hormone binding globulin (SHBG) levels were measured. Calculated free estradiol and free testosterone index (FTI), which reflect the biologically active fraction of those hormones, were used for analyses. We performed Pearson’s correlation and linear regression analysis across the whole cohort, and also performed the subgroup analyses in each gender. Results: For the entire subjects, we did not find any associations of sex hormones, gonadotropins, and SHBG with global PiB retention. However, subgroup analyses showed that FTI (b1⁄4-9.240, t1⁄4-2.92, p1⁄40.005) and FSH (b1⁄4-0.128, t1⁄4-2.73, p1⁄40.008) levels are associated with global PiB retention in female, while SHBG (b1⁄40.187, t1⁄42.75, p1⁄40.008) level was related to global PiB retention in male. Conclusions:These findings suggest that there might be gender-specific differences in the way how sex hormones and gonadotropins affect cerebral Ab deposition.