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IC‐P‐015: Amyloid‐Positive Versus Negative AMCI: Similarities and Differences in Neuropsychology and Neuroimaging Profiles
Author(s) -
Tomadesso Clemence,
de La Sayette Vincent,
Mutlu Justine,
Flores Robin,
Villemagne Victor L.,
Egret Stephanie,
Eustache Francis,
Chetelat Gael
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.025
Subject(s) - neuroimaging , neuropsychology , atrophy , psychology , cognition , amyloid (mycology) , hippocampal formation , neuroscience , alzheimer's disease neuroimaging initiative , medicine , audiology , cognitive impairment , pathology
tion and neuropsychological tests including the SubjectiveMemory Complaints Questionnaire(SMCQ), Seoul Informant Report Questionnaire for Dementia(SIRQD), Clinical Dementia Rating(CDR), CERAD neuropsychological battery, stroop test as well as Apolipoprotein E(APOE) allele typing, MRI, and Pittsburgh compound B PET(Pib PET). PiB PET Images were classified as amyloid deposition positive if the mean C-PiB retention value was over 1.4 in one of the following regions: the frontal, lateral temporal, lateral parietal, precuneus/posterior cingulate cortices. In MRI, we measured mean gray matter(GM) thickness using freesurfer. Results:Among 30 subjects, 18 subjects classified as amyloid deposition positive group(MCI+). Compared to amyloid deposition negative(MCI-) group, MCI+ group showed significantly higher APOE e4 allele frequency, lower word list recall, higher stroop color-word test scores and lower mean cortical thickness in MRI. When amyloid deposition positivity prediction models based on logistic regression analyses were compared, the combined model of CERAD word list recall, stroop color word test, and MRI mean cortical thickness was the best discrimination model after adjusting age, education, and APOE e4 allele frequency(the prediction accuracy 90 %). Conclusions:Our results suggest that the combination of verbal delayed recall, stroop color-word test, and cortical thickness on MRI may be useful for the discrimination of amyloid deposition status.