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IC‐P‐014: Combination of Verbal Delayed Recall, Stroop Color‐Word, and Mri Can Be Utilized for The Discrimination of Amyloid Deposition Status in MCI Individuals
Author(s) -
Sohn Bo Kyung,
Kim Jee Wook,
Yi Dahyun,
Byun Min Soo,
Choe Young Min,
Choi Hyo Jung,
Baek Hyewon,
Lee Jun Ho,
Kim Hyun Jung,
Kim Shin Gyeom,
Seo Eun Hyun,
Han Ji Young,
Woo Jong Inn,
Lee Dong Young
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.024
Subject(s) - stroop effect , precuneus , pittsburgh compound b , psychology , clinical dementia rating , audiology , dementia , neuropsychology , apolipoprotein e , posterior cingulate , medicine , cognition , neuroscience , disease
high or low Ab in neocortical and striatal (caudate and putamen) aggregates, using Gaussian mixture models. We evaluated changes in Ab classification between baseline and follow-up Ab-PET (0.95.1 years), and the association between Ab classification at baseline and longitudinal memory performance, longitudinal hippocampal volume, and cross-sectional tau-PET ([18F]-T807/AV1451). Results:Both cortical and striatal AV45/PiB have bimodal distribution (Lilliefors KS-test>0.1, p<0.001), allowing categorization. Striatal Ab is elevated only if cortical Ab is elevated, classifying subjects in three Ab-stages: stage 0: low-Ab in both regions, stage 1: high-cortical but low-striatal Ab, stage 2: high-Ab in both regions. Less than 1% of subjects have an indeterminate stage: high-striatal but low-cortical Ab (Table 1, Figure 1). Subjects with Ab-stage 0 at baseline are more likely to transition to high cortical than to high striatal Ab after follow-up (ADNI: c1⁄426.2, p<0.001; HABs: c1⁄44.9, p1⁄40.026). Ab-stage 1 subjects are more likely to transition to high striatal Ab than Ab-stage 0 subjects (ADNI: c1⁄419.6, p<0.001; HABs: c1⁄433.5, p<0.001, Figure 2). Subjects with high-striatal Ab at baseline are more at-risk for longitudinal memory decline, longitudinal hippocampal atrophy, and tau deposition than subjects with low-striatal Ab, even among subjects with high-cortical Ab (Table 2). Conclusions: Both datasets provide evidence that striatal Ab accumulation occurs after neocortical Ab, at later disease stages. Striatal Ab is a risk factor for memory decline, hippocampal atrophy, and tau deposition, making it a potentially useful biomarker for tracking disease progression. Further work is ongoing to determine the potential added value of striatal Ab for predicting cognitive decline in preclinical stages.