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Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease
Author(s) -
Gispert Juan Domingo,
SuárezCalvet Marc,
Monté Gemma C.,
Tucholka Alan,
Falcon Carles,
Rojas Santiago,
Rami Lorena,
SánchezValle Raquel,
Lladó Albert,
Kleinberger Gernot,
Haass Christian,
Molinuevo José Luis
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.005
Subject(s) - cerebrospinal fluid , precuneus , magnetic resonance imaging , fractional anisotropy , neurodegeneration , pathology , diffusion mri , brain size , neuroscience , alzheimer's disease , medicine , psychology , disease , cognition , radiology
TREM2 is involved in the regulation of inflammatory response and phagocytosis. A soluble fragment (sTREM2) is often found abnormally increased in cerebrospinal fluid (CSF) in Alzheimer's disease (AD). Methods One hundred fourteen participants (45 control, 19 preclinical, 27 mild cognitive impairment [MCI], and 23 AD) underwent CSF sTREM2 determination and magnetic resonance imaging (MRI). We studied the association between CSF sTREM2, gray matter volume, and water motion diffusivity and anisotropy across groups. Results In MCI patients, a positive correlation between CSF sTREM2 and gray matter volume was found in the bilateral inferior and middle temporal cortices, precuneus, the supramarginal, and angular gyri, after controlling by age, sex, and p‐tau. A negative correlation with mean diffusivity was detected in overlapping regions, among others. Discussion In early AD, augmented CSF sTREM2 levels correspond with cerebral MRI features typical of brain swelling, supporting a role for TREM2 in the regulation of the neuroinflammatory response to early neurodegeneration.