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Waist circumference is correlated with poorer cognition in elderly type 2 diabetes women
Author(s) -
West Rebecca K.,
RavonaSpringer Ramit,
Heymann Anthony,
Schmeidler James,
Leroith Derek,
Koifman Keren,
D'Arcy Ryan C.N.,
Song Xiaowei,
GuerreroBerroa Elizabeth,
Preiss Rachel,
Hoffman Hadas,
Sano Mary,
Silverman Jeremy M.,
SchnaiderBeeri Michal
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.03.017
Subject(s) - waist , type 2 diabetes , circumference , cognition , confounding , categorization , dementia , medicine , episodic memory , diabetes mellitus , gerontology , psychology , obesity , psychiatry , endocrinology , disease , artificial intelligence , geometry , mathematics , computer science
Waist circumference is associated with type 2 diabetes (T2D) and cognition, yet the relationship between waist circumference and cognition in individuals with T2D is not well understood. Methods We studied the relationship of waist circumference with five cognitive outcomes (executive functioning, language/semantic categorization, attention/working memory, episodic memory, and an overall cognition measure) in 845 cognitively normal elderly with type 2 diabetes (T2D). Results In women, waist circumference was correlated with significantly lower language and/or semantic categorization performance ( P < .0001), executive functioning ( P = .026), and overall cognition ( P = .003) after controlling for age, education, BMI, and cardiovascular, diabetes‐related, APOE ε4, and inflammatory potential confounders. Attention/working memory ( P = .532) and episodic memory ( P = .144) were not associated with waist circumference. These correlations were not found in men. Discussion These results suggest that central adiposity in elderly women with T2D may increase their risk for dementia.