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Individual estimates of age at detectable amyloid onset for risk factor assessment
Author(s) -
Bilgel Murat,
An Yang,
Zhou Yun,
Wong Dean F.,
Prince Jerry L.,
Ferrucci Luigi,
Resnick Susan M.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.08.166
Subject(s) - apolipoprotein e , pittsburgh compound b , age of onset , amyloid (mycology) , medicine , risk factor , longitudinal study , ageing , oncology , gerontology , disease , psychology , alzheimer's disease , pathology
Individualized estimates of age at detectable amyloid‐beta (Aβ) accumulation, distinct from amyloid positivity, allow for analysis of onset age of Aβ accumulation as an outcome measure to understand risk factors. Methods Using longitudinal Pittsburgh compound B (PiB) positron emission tomography data from Baltimore Longitudinal Study of Aging, we estimated the age at which each PiB+ individual began accumulating Aβ. We used survival analysis methods to quantify risk of accumulating Aβ and differences in onset age of Aβ accumulation in relation to APOE ε4 status and sex among 36 APOE ε4 carriers and 83 noncarriers. Results Age at onset of Aβ accumulation for the APOE ε4− and ε4+ groups was 73.1 and 60.7, respectively. APOE ε4 positivity conferred a threefold risk of accumulating Aβ after adjusting for sex and education. Discussion Estimation of onset age of amyloid accumulation may help gauge treatment efficacy in interventions to delay symptom onset in Alzheimer's disease.