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P4‐316: The dual lsd1/maob inhibitor ory2001 prevents the development of the memory deficit in samp8 mice through induction of neuronal plasticity and reduction of neuroinflammation
Author(s) -
Buesa Carlos,
Mascaró Cristina,
Rotllant David,
Griñan-Ferré Christian,
Pallàs Mercè,
Maes Tamara
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - Italian
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.08.146
Subject(s) - neuroinflammation , monoamine oxidase b , neurodegeneration , hippocampal formation , biology , chemistry , pharmacology , microbiology and biotechnology , inflammation , neuroscience , biochemistry , medicine , monoamine oxidase , enzyme , immunology , disease
P4-315 EVALUATING AMYLOID-BETA PROCESSING USING NOVEL GAMMA-SECRETASE MODULATORS IN PRECLINICAL ANIMAL MODELS Kathleen M. Wood, Cathleen Gonzales, Feng Pan, Nikolay Pozdnyakov, Michael Marconi, Ashley Robshaw, David Riddell, Dmitri Volfson, Martin Pettersson, Eva Hajos-Korcsok, Kelly R. Bales, Pfizer Inc., Cambridge, MA, USA; Merck, Cambridge, MA, USA; Merck, Indianapolis, IN, USA. Contact e-mail: kathleen.m. wood@pfizer.com