Premium
P4‐271: Interaction between education and computerized semantic indices of verbal fluency
Author(s) -
Pakhomov Serguei,
Eberly Lynn,
Jones David T.,
Knopman David S.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.08.100
Subject(s) - dementia , verbal fluency test , psychology , semantic memory , fluency , clinical psychology , cognition , cohort , audiology , developmental psychology , disease , neuropsychology , medicine , psychiatry , mathematics education
8 and 18 months and to evaluate whether the antiepileptic drug Levetiracetam have any effect on spontaneous seizures. Methods: Video-EEG/EMG monitoring over 24-hrs of the light dark cycle was carried out at baseline. At 8 months, network excitability was examined by quantifying susceptibility of pentylenetetrazole (PTZ) (30 mg/kg) to induce seizures. At 18 months, the frequency of epileptiform SWD was repeatedly quantified before and after acute and sub-chronic administration of leviracetam (150 mg/kg). Results: At 8 months, APP/PS1 had no spontaneous seizures across different vigilance states. PTZ provoked seizures at shorter latencies in APP/PS1 mice compared to littermate controls, which were associated with a significant increase in EEG power within 4-30 Hz frequency range. These changes were short lasting and rapidly abolished. At 18 months, 60% of APP/PS1 mice expressed spontaneous non-convulsive seizures (30-40s duration) and epileptiform SWD activity at shorter duration i.e. 0.3 -6.0 s. The observed behavioral correlate included motor arrest accompanied by subtle myoclonic jerks. Conclusions: Consistent with previous reports, aged APP/PS1 mice exhibit high incidence of unprovoked epileptic activity, whereas no such abnormalities were detected at a young age. Follow-up studies are underway to investigate whether acute or sub-chronic Levetiracetam can reduce or prevent this epileptiform activity.