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P4‐269: Relationships between baseline biomarkers and subsequent cognitive decline in cognitively unimpaired PSEN1 E280A mutation carriers from the colombian kindred with autosomal dominant Alzheimer's disease
Author(s) -
Quiroz Yakeel T.,
Protas Hillary,
Chen Kewei,
Roontiva Auttawut,
Thiyyagura Pradeep,
Fagan Anne M.,
Shah Aarti,
Gutierrez Madelyn,
Londono Marisol,
Giraldo Margarita,
Munoz Claudia,
Tirado Victoria,
Velilla Lina,
Garcia Gloria,
Jaimes Sehily Y.,
Langbaum Jessica B.,
Tariot Pierre N.,
Sperling Reisa A.,
Lopera Francisco,
Reiman Eric M.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.08.098
Subject(s) - psen1 , cognitive decline , presenilin , medicine , cognition , cerebrospinal fluid , alzheimer's disease , psychology , disease , oncology , dementia , neuroscience
VFT Normal 11 10 0.031* 6 15 0.151 12 9 0.070 Mildly impaired 5 11 2 14 7 9 Moderately impaired 4 21 2 23 6 19 mBNT Normal 14 16 0.063 8 22 0.058 15 15 0.323 Mildly impaired 3 13 2 14 5 11 Moderately impaired 3 13 0 16 5 11 MMSEKC Normal 1 2 0.056 0 3 0.002* 3 0 0.014* Mildly impaired 6 3 5 4 6 3 Moderately impaired 13 37 5 45 16 34 WLMT Normal 9 11 0.088 6 14 0.103 10 10 0.451 Mildly impaired 6 8 2 14 6 8 Moderately impaired 5 23 2 26 9 19 CPT Normal 15 25 0.111 9 31 0.167 19 21 0.295 Mildly impaired 5 9 1 13 4 10 Moderately impaired 0 8 0 8 2 6 WLRT Normal 7 2 0.005* 4 5 0.042* 6 3 0.215 Mildly impaired 2 10 1 11 4 8 Moderately impaired 11 30 5 36 15 26 WLRcT Normal 11 9 0.021* 7 13 0.014* 10 10 0.301 Mildly impaired 4 9 0 13 3 10 Moderately impaired 5 24 3 26 12 17 CRT Normal 6 4 0.116 4 6 0.051 6 4 0.333 Mildly impaired 2 7 2 7 4 5 Moderately impaired 12 31 4 39 15 28