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P4‐268: Association between degenerative changes in brain and cognitive functions in Alzheimer's disease
Author(s) -
Joo Soo Hyun,
Lee Chang Uk
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.08.097
Subject(s) - hyperintensity , boston naming test , verbal fluency test , atrophy , psychology , neurocognitive , wechsler adult intelligence scale , audiology , alzheimer's disease , dementia , medicine , cognition , disease , pathology , neuropsychology , magnetic resonance imaging , neuroscience , radiology
Soo Hyun Joo, Chang Uk Lee, Seoul St. Mary’s Hospital, Medical College, The Catholic University of Korea, Seoul, South Korea. Contact e-mail: purple-sh@hanmail.net Background:The aim of this study is to investigate the correlation between degenerative changes in brain (i.e. global cortical atrophy, medial temporal atrophy, white matter hyperintensities) and neurocognitive dysfunction in Korean patients with Alzheimer’s disease. Methods: A total of 62 elderly subjects diagnosed with Alzheimer’s disease were included in this study. The degenerative changes in brain MRI were rated with standardized visual rating scales (GCA, MTA, Fazekas scale) and the subjects were divided into two groups according to the degree of degeneration for each scale. Cognitive function was evaluated with CERAD-K (Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease) and several clinical features, including apolipoprotein E ε4 status, lipid profile and thyroid hormones, were also examined. Chi-square test was performed to