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P4‐267: Caudate volume change in primary progressive aphasia with motor speech symptoms
Author(s) -
Eastman Jennifer Ann,
Martersteck Adam,
Rademaker Alfred,
Mesulam M.-Marsel,
Weintraub Sandra,
Rogalski Emily J.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.08.096
Subject(s) - caudate nucleus , primary progressive aphasia , putamen , atrophy , psychology , audiology , aphasia , motor symptoms , medicine , parkinson's disease , neuroscience , disease , pathology , frontotemporal dementia , dementia
magnetic resonance imaging (fMRI) to assess the PFC-involved neural connections. Results:As expected, we found greater IIVRT in the MCI group compared to HCs. In the MCI group, IIVRT was positively correlated with the degree of connectivity in the fronto-basal ganglia circuit, and negatively correlated with the ECN in the right hemisphere. Conversely, IIVRT was negatively correlated with connectivity in fronto-basal ganglia circuit, and had no correlation with the ECN in the HC group. Conclusions: The altered relationship between IIVRT and two PFC-involved neural connections in MCI may indicate an early marker of the neurodegenerative process, though further work determining the causal link is needed.