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P4‐265: Altered functional connectivity of prefrontal cortex underpins the abnormality of intra‐individual variability in reaction time in mild cognitive impairment
Author(s) -
Ren Ping,
Wu Rachel,
Mapstone Mark,
Lin Feng
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.08.094
Subject(s) - basal ganglia , prefrontal cortex , neuroscience , psychology , abnormality , cognition , functional magnetic resonance imaging , executive functions , audiology , medicine , central nervous system , psychiatry
Figure 3. Greater p-tau/Ab42 is associated with myelin damage. Significant regions signify negative relationship between MWF and p-tau/Ab42, correcting for age (p<0.05, corrected for FWE). Douglas C. Dean, III, Jitka Sojkova, Samuel Hurley, Patrick O’Grady, Christybelle-Marie Canda, Nancy J. Davenport, LeAnn DeRungs, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Mark A. Sager, Sanjay Asthana, Sterling C. Johnson, Andrew L. Alexander, Barbara B. Bendlin, Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, USA; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Geriatric Research Education and Clinical Center, Wm. S. Middleton Veterans Hospital, Madison, WI, USA; Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, United Kingdom; Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer’s Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; University of Gothenburg, M€olndal, Sweden; University College London, Institute of Neurology, London, United Kingdom; Wisconsin Alzheimer’s Disease Research Center, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Contact e-mail: deaniii@wisc.edu