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P4‐256: Structural differences in cognitively normal, mild cognitive impairment, and Alzheimer's disease individuals: A novel study based on brain symmetry
Author(s) -
Dai Peng,
Gwadry-Sridhar Femida,
Bauer Michael,
Borrie Michael
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.08.085
Subject(s) - neuroimaging , brain size , atrophy , psychology , neuroscience , disease , human brain , medicine , magnetic resonance imaging , pathology , radiology
Background: The association of blood pressure (BP) and dementia in the elderly is debated. Whereas hypertension in mid-life appears to increase the risk of Alzheimer’s dementia (AD); lower BP in the elderly is associated with a greater risk of cognitive decline. White matter lesions (WML) are the result of impaired cerebral blood flow, possibly due to insufficient perfusion pressure. The hippocampus, an early site of AD pathology, is also among the brain structures most sensitive to hypoperfusion. We tested the hypothesis that elderly normotensive subjects with WML represent a group suffering from subclinical cerebral hypoperfusion, which increases their risk for AD. We examined 24-hour ambulatory blood pressure (ABP), hippocampal volume and memory in four groups of sub-