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P4‐253: Effects of metabolic syndrome, antihypertensive medications, and statins on PiB deposition in cognitively normal subjects
Author(s) -
Glodzik Lidia,
Rusinek Henry,
Pirraglia Elizabeth,
Tsui Wai,
Mosconi Lisa,
Li Yi,
McHugh Pauline,
Murray John,
Williams Schantel,
Randall Catherine,
Butler Tracy,
Deshpande Anup,
Vallabhajosula Shankar,
DeLeon Mony
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.08.082
Subject(s) - medicine , pittsburgh compound b , metabolic syndrome , endocrinology , amyloid (mycology) , obesity , diabetes mellitus , cognitive decline , disease , cardiology , alzheimer's disease , dementia , pathology
on MMSE. The average age was 79.8 65.9 year old. The disease duration is 3.3 6 2.0 years. They are divided into two groups according to the specific binding ratio (SBR) of I-FP-CIT SPECT. The SBR is derived from a measure of total striatal count (TossiciBolt L et al, Eur J Nucl Med Mol Imaging 2006, 33:1491). The patients with less than 4.0 on the SBR were referred to the low DAT group (L-DAT, N1⁄4 11) and those with more than 4.0 were designated to the normal DAT group (N-DAT, N 1⁄4 8). A three-dimensional stereotactic surface projection (3D-SSP) analysis of SPECT was performed using the interface software iSSP5 and iSSP35_2tZ (Nihon Medi-Physics Corporation,Tokyo, Japan).We used Z-score 2 as a cut off value. Results: There was no significant difference of age, disease duration and score ofMMSE and UPDRS part III between L-DAT and N-DAT group. The left lateral and bilateral medial parietal lobe demonstrated decreased rCBF in the all patients examined compared with age-matched controls. When we compared rCBF SPECT between L-DAT and N-DAT group, L-DAT group showed lower rCBF in the bilateral medial frontal and medial parietal lobe than N-DAT group. Conclusions: Low rCBF in the medial prefrontal cortex may be helpful to differentiate DLB from AD.