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P4‐226: CSF Aβ42/40 and Aβ42/38 ratios by prm mass spectrometry or elisa: Improved biomarkers of Alzheimer's disease
Author(s) -
Janelidze Shorena,
Pannee Josef,
Vanderstichele Hugo,
Zetterberg Henrik,
Blennow Kaj,
Hansson Oskar
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.08.054
Subject(s) - dementia , medicine , gastroenterology , cerebrospinal fluid , dementia with lewy bodies , cohort , vascular dementia , neurology , pathology , disease , psychiatry
prior to death. Subjects were grouped into one of three ApoE subgroups (ε21⁄4ε2ε3, ε31⁄4ε3ε3, ε41⁄4ε3ε4+ ε4ε4) and ε3 was used as the reference. Results:After adjusting for only demographic variables (age, education, gender), the key variables associated with cognition were: docosahexaenoic acid (DHA)-PlsEtn (Coef:0.620, p1⁄48.7E-09, r1⁄40.329, n1⁄499), tangles (Coef: -0.552, p1⁄44.0E-06, r1⁄40.267, n1⁄499), amyloid (Coef: -0.394, p1⁄41.1E-04, r1⁄40.150, n1⁄499), ApoE ε4 (Coef: -0.369, p1⁄44.2E-03, r1⁄40.131, n1⁄491), Dihydroxyacetone phosphate alkyltransferase (DHAPAT, Coef: 0.307, p1⁄42.7E-02, r1⁄40.109, n1⁄494). Neither amyloid nor ApoE ε4 was associated with cognition in combined models of these variables where brain DHA-PlsEtn level, tangle density and age showed independent associations with cognition. ApoE ε4 was the dominant variable associated with amyloid (Coef: 1.185, p1⁄45.3E-07, r1⁄40.297, n1⁄491). Overall, 46% of the variance in cognition was associated with DHA-PlsEtn, tangles, DHAPAT, and age. Amyloid (Coef:-0.025 p1⁄41.4E-03, r1⁄40.084, n1⁄499), ApoE ε4 (Coef: -0.044, p1⁄42.1E-02, r1⁄40.081, n1⁄492), and tangles (Coef:-0.044 p1⁄41.1E-04, r1⁄40.153, n1⁄4100) were associated with DHA-PlsEtn levels. Conclusions: Of the variables investigated, temporal cortex DHA-PlsEtn level exhibited the strongest association with cognition. Only tangles and age were associated with cognition independent of brain DHA-PlsEtn levels.