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P4‐223: Serum plasmalogens, ApoE genotype, and the odds of converting from nci to MCI/ad or from MCI to Alzheimer's disease: A longitudinal analysis in elderly persons
Author(s) -
Mochizuki Asuka,
Senanayake Vijitha,
Chitou Bassirou,
Smith Tara,
Goodenowe Dayan B.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.08.051
Subject(s) - apolipoprotein e , medicine , odds ratio , genotype , cognitive impairment , cognitive decline , gastroenterology , alzheimer's disease , oncology , psychology , disease , gerontology , dementia , biology , genetics , gene
both in the rat (p<0.039) as well as in human retinal tissues (p<0.022) and corroborated soluble amyloid complex formation with neuroserpin. Conclusions: Association of the protease inhibitor neuroserpin with amyloid b aggregates in the brain and retina may lead to impairment of the plasmin mediated amyloid b clearance mechanism thereby making Ab deposits more resistant to digestion. Modulation of Ab-neuroserpin interaction to enhance the penetration of endogenous proteolytic mechanisms and promote the degradation of Ab fibrils by may thus be a novel neuroprotective approach in AD.