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P4‐179: Young to middle‐aged dogs with high basal Aβ42 CSF level demonstrate learning impairment compared to dogs with low basal CSF Aβ42
Author(s) -
Araujo Joseph A.,
Borghys Herman,
Brooks Melissa,
Broeck Bianca,
Dhuyvetter Deborah
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.08.007
Subject(s) - basal (medicine) , beagle , cerebrospinal fluid , atrophy , psychology , medicine , biomarker , cognition , pathology , physiology , neuroscience , biology , insulin , biochemistry
reported [Barthel2011]. Results: Cross-sectional effect size was larger for SUVR methods including subcortical white matter as a reference region, and highest using a composite reference region including subcortical white matter, brainstem, and whole-cerebellum (Cohen’s D1⁄43.88). Lowest effect size was obtained using the cerebellar grey reference (2.66). Accuracy was higher using the composite reference and a cutpoint of 0.845 (sensitivity1⁄40.979, specificity1⁄40.978), compared to the cerebellar grey referencewith a cutpoint of 1.346 (sensitivity1⁄40.917, specificity1⁄40.956). The Freesurfer method performed slightly better than the AALmethod using the cerebellar grey reference. Conclusions: Comparing SUVR cutpoints to visual assessment, an SUVR method using a subcortical white matter reference region appears superior to methods using cerebellar references. These results can be influenced by the visual assessment method used which focuses on comparing the target intensity in the cortical gray matter versus the subcortical white matter. [Landau2013] J Nucl Med 54:1–8. [Barthel2011] Lancet Neurol 10:424-35.