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O5‐03‐04: Clinical characteristics and course of dlb: Results from a large longitudinal multicentre cohort
Author(s) -
Kramberger Milica G.,
Olmo Joseph Garre,
Lemstra Afina W.,
Londos Elisabet,
Bonanni Laura,
Elder Greg,
Winblad Bengt,
Jan de Jong Frank,
Nobili Flavio,
Stefanova Elka,
Petrova Maria,
Falup-Pecurariu Cristian,
Rektorova Irena,
Biundo Roberta,
Weintraub Daniel,
Aarsland Dag
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.460
Subject(s) - clinical dementia rating , cohort , dementia , medicine , dementia with lewy bodies , cognitive decline , mini–mental state examination , disease
scores were associated with higher IQCODE scores (greater decline) (b 1⁄4 .318, t(424) 1⁄4 6.88, p< .001) when gender and education were controlled for. Higher levels of hallucinations (b 1⁄4 .178, p1⁄4.003), depression (b 1⁄4 .203, p1⁄4.001), apathy (b 1⁄4 .242, p< .001), irritability (b 1⁄4 .161, p1⁄4 .005), and greater changes in appetite (b 1⁄4 .103, p1⁄4.028) were linked to poorer informant-rated cognitive function. In men, higher levels of hallucinations (b 1⁄4 .159, p1⁄4.01), depression (b 1⁄4 .236, p1⁄4.007), apathy (b 1⁄4 .19, p1⁄4.034), and greater changes in appetite (b 1⁄4 .145 p1⁄4.027) were associated with poorer cognitive function. For women, only higher levels of apathy (b 1⁄4 .253, p1⁄4.003) were associated with to poorer informant-rated cognitive function. Conclusions: This study provides new and important evidence on the association between neuropsychiatric symptoms and informant-rated cognitive function in healthy older adults. These findings provide support for the concept of MBI and highlight the need to consider gender differences.