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O5‐01‐02: Examining relations of age and beta‐amyloid with tau deposition measured using 18F‐AV‐1451 in cognitively normal older adults
Author(s) -
Lockhart Sam,
Schöll Michael,
Schonhaut Daniel,
Ossenkoppele Rik,
Vogel Jacob W.,
Baker Suzanne,
Schwimmer Henry,
Rabinovici Gil D.,
Jagust William J.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.446
Subject(s) - voxel , white matter , nuclear medicine , fornix , psychology , atrophy , medicine , cartography , neuroscience , hippocampus , magnetic resonance imaging , geography , radiology
between deposits of Ab and local GM volume in lateral temporal, parietal and frontal regions, as well as medial and inferior temporal areas (Figure A). Tau and Ab deposits display direct in-situ associations -positive correlationsin heteromodal areas of frontal, parietal and temporal lobes, most highly in inferior-lateral temporal cortex (Figure B). Inferior-lateral temporal cortex seems to be critical to understand the in-situ and distributed relationships between Tau and Ab pathology (Figure B). Conclusions: At preclinical stages of Alzheimer’s disease, Tau and Ab deposits show strong spatial interdigitations in heteromodal and associative areas of the cortical mantle, particularly in lateral temporal and frontal lobes. However, Tau and Ab deposits associate with distinctive spatial patterns of brain atrophy.