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F5‐01‐04: Lifestyle effects on Alzheimer's disease neuroimaging biomarkers: Moving towards preclinical Alzheimer's disease
Author(s) -
Arenaza-Urquijo Eider M.,
Wirth Miranka
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.426
Subject(s) - neuroimaging , disease , neuroscience , neuroprotection , cognition , psychology , cognitive decline , alzheimer's disease , medicine , dementia , pathology
years compared with low lifetime intellectual enrichment (25percentile) (Vemuri et. al. JAMA Neurology 2014); and 2) high lifetime intellectual enrichment appeared to offset the deleterious effect of vascular and amyloid pathologies on the cognitive trajectories (Vemuri et. al. Brain 2015). We will present new data where we studied 393 non-demented (340 cognitively normal, 53 MCI) participants in Mayo Clinic Study of Aging (MCSA) who had complete intellectual and physical lifestyle measures available and also had at least two separate complete set of AD biomarker (PIB, FDG and MRI) measurements available. We built three separate linear mixed models to investigate the effect of demographics (age, sex, APOE4) and lifestyle variables (Education/occupation, mid/latelife intellectual lifestyle score, mid-life physical activity score and late-life physical activity score) on each of the three AD biomarker outcome variables. Results: We found that older age and APOE4 genotype were significantly associated with worse baseline global PIB scores and FDG values (p<0.001) and none of the variables studied influenced the rate of accumulation. Older age was significantly associated with worse hippocampal volumes (p<0.001) and significantly influenced the annual rate of change in hippocampal volume (p1⁄40.0053). None of the lifestyle variables influenced the biomarker trajectories. Conclusions: Lifestyle variables did not influence the baseline and change in AD biomarkers. This study along with our previous studies support the hypothesis that intellectual lifestyle influences cognitive performance but does not influence AD biomarker trajectories.