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O4‐08‐04: Heterogeneous histopathology of caa‐related cortical microbleeds
Author(s) -
Veluw Susanne J.,
Biessels Geert Jan,
Klijn Catharina J.M.,
Rozemuller Annemieke
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.390
Subject(s) - histopathology , fluid attenuated inversion recovery , medicine , hemosiderin , hyperintensity , pathology , cerebral amyloid angiopathy , coronal plane , voxel , white matter , magnetic resonance imaging , nuclear medicine , radiology , dementia , disease
quantification. However, cerebellar plaques may be present in Alzheimer disease (AD). The aim of this study was to assess the influence of cerebellar plaques in FBB SUVR, when using cerebellar gray matter as the reference. Methods: Neuropathological assessment of cerebral (frontal, occipital, anterior and posterior cingulate) cortex and cerebellar cortex tissue from 87 end of life patients (64 AD, 14 other dementia, 9 non-demented aged volunteers; 80.4610.2 yrs) who underwent a FBB PET before death was performed using the Bielschowsky silver stain and Amyloid b (Ab) immunohistochemistry to quantify neuritic/cored and diffuse plaques, as absent, sparse, moderate and frequent. Mean cortical SUVRs were compared among brains with different cerebellar plaque loads. Results:None from the 83 evaluable cerebellar samples showed frequent cerebellar plaques. Only 1 sample showed both sparse neuritic/cored and sparse diffuse plaques. Sparse diffuse pla-