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O4‐08‐02: Impact of morphologically distinct amyloid ß (Aß) deposits on 18F‐florbetaben (FBB) PET scans
Author(s) -
Leverenz James B.,
Sabri Osama,
Catafau Ana M.,
Barthel Henryk,
Seibyl John,
Ghetti Bernardino,
Ironside James W.,
Bullich Santiago,
Schulz-Schaeffer Walter J.,
Hoffman Anja
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.388
Subject(s) - posterior cingulate , grey matter , pathology , medicine , immunohistochemistry , cortex (anatomy) , nuclear medicine , magnetic resonance imaging , white matter , neuroscience , psychology , radiology
species. We, therefore, investigated the region specific correlation between in vivo [C]PiB retention and the postmortem burden of neuritic plaques (NPs), diffuse plaques (DPs) or cerebral amyloid angiopathy (CAA). Methods:A total of 33 subjects with PiB-PET during life and postmortem neuropathologic examination (31 with dementia and 2 with MCI, mean age at PET1⁄466.768.1, interval from PET to autopsy 3.261.8 years) were assessed. PiB SUVR (gray cerebellum reference) and post-mortem Ab burden were analyzed in five cortical ROIs: anterior cingulate, middle frontal, inferior temporal, angular and calcarine. PiB SUVRs were extracted in template space using customized ROIs matching regions sampled at autopsy. NP were quantified using CERAD, and DP/ CAA and were classified by the pathologist as: none to sparse and moderate to frequent. PET to autopsy correlations were examined using multi-linear regression. Results: The overall prevalence of pathology was 59.5% none-sparse/40.5% moderate-frequent for NP, 52.8%/47.2% for DP and 82.2%/17.8% for CAA. When examined separately (adjusting for PET-autopsy interval), moderate to severe NP (b1⁄40.411w0.863, p<0.05) and DP (b1⁄40.264w0.879, p<0.05) each correlated with PiB SUVR in all regions, while moderate to severe CAA predicted high PiB SUVR in the anterior cingulate and calcarine regions (b1⁄40.393/0.332, p1⁄40.004/0.004). When NP and DP or CAAwere included in the same model, moderate to severe NP correlated with PiB SUVR in all regions (b1⁄40.362w0.946, p<0.05), whereas DP in the anterior cingulate (b1⁄40.486, p1⁄40.024) independently correlated with PiB SUVR after controlling for NP. The significance of CAA disappeared after controlling for NP. Tests for trends across dose dependent amyloid burdens (none, sparse, moderate and frequent) showed that increased NP burdens in all regions and DP in the anterior cingulate and angular regions associated with high PiB SUVR. Conclusions: In a dementia clinic population, regional PiB signal was dominated by NP, though DP contributed to signal in some regions. These findings have implications for clinical and research applications of amyloid PET.