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O3‐13‐01: Whole genome sequencing of late‐onset Alzheimer's disease patients from genetic isolate
Author(s) -
Grigorenko Anastasia,
Gusev Fedor,
Reshetov Denis,
Andreeva Tatiana,
Shagam Lev,
Goltsov Andrey,
Kirgizova Vitalina,
Zolotareva Olga,
Protasova Maria,
Lee Sven J.,
Amin Najaf,
Oostra Ben A.,
Duijn Cornelia M.,
Rogaev Evgeny
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.309
Subject(s) - genetics , biology , population , indel , genome wide association study , single nucleotide polymorphism , gene , genotype , medicine , environmental health
Age (years) -0.03 (-0.04, -0.02) <0.001 -0.04 (-0.04, -0.03) <0.001 -0.03 (-0.04, -0.03) <0.001 Smoking Never (ref.) Former/Current -0.04 (-0.13,0.06) 0.47 0.10(0.02,0.18) 0.02 0.04 (-0.03,0.12) 0.26 Body mass index <22 kg/m -0.01 (-0.18,0.16) 0.88 -0.08 (-0.23,0.06) 0.27 -0.04 (-0.17,0.09) 0.57 22-24.9 kg/m (ref.) 25-29.9 kg/m 0.02 (-0.09,0.12) 0.74 0.00 (-0.09,0.09) 0.94 0.01 (-0.07,0.09) 0.82 30+ kg/m 0.10 (-0.05,0.25) 0.18 0.03 (-0.10,0.16) 0.61 0.06 (-0.06,0.17) 0.34 Physical activity, MET-hr/wk First quartile (ref.) Second quartile 0.04 (-0.04,0.17) 0.50 0.03 (-0.08,0.14) 0.57 0.01 (-0.09,0.11) 0.83 Third quartile 0.01 (-0.12,0.14) 0.86 0.00 (-0.11,0.11) 0.99 -0.02 (-0.12,0.08) 0.70 Fourth quartile 0.08 (-0.05,0.21) 0.25 0.01 (-0.11,0.12) 0.89 0.00 (-0.10,0.11) 0.95 Alcohol, drinks/day None (ref.) 1-2 0.09 (-0.01,0.19) 0.06 0.03 (-0.05,0.11) 0.45 0.05 (-0.03,0.12) 0.21 >2 -0.03 (-0.16,0.11) 0.67 -0.02 (-0.13,0.10) 0.77 -0.03 (-0.13,0.07) 0.56 Nut intake, times/day First quartile (ref.) Second quartile 0.10 (-0.02,0.23) 0.10 0.11 (0.01,0.22) 0.04 0.11 (0.02,0.21) 0.02 Third quartile 0.15 (0.01,0.28) 0.03 0.16 (0.05,0.25) 0.005 0.18 (0.07,0.28) 0.001 Fourth quartile 0.08 (-0.06,0.21) 0.26 0.07 (-0.04,0.19) 0.21 0.09 (-0.01,0.20) 0.09 Diabetes -0.18 (-0.34, -0.02) 0.03 0.09 (-0.04,0.23) 0.18 -0.05 (-0.18, 0.07) 0.42 Hypertension -0.07 (-0.16,0.02) 0.12 -0.08 (-0.16,-0.01) 0.03 -0.08 (-0.15, -0.01) 0.03 Myocardial infarction 0.10 (-0.08,0.27) 0.26 0.02 (-0.13,0.16) 0.80 0.05 (-0.09,0.18) 0.48