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O3‐09‐03: Paroxysmal disturbances of functional connectivity in amyloid positive, cognitively intact elderlies
Author(s) -
Mueller Susanne G.,
Yohannes Seghel,
Truran-Sacrey Diana,
Buckley Shan,
Weiner Michael W.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.287
Subject(s) - resting state fmri , amyloid (mycology) , neuroscience , psychology , medicine , pathology
the hub region away from posterior regions in the higher frequency bands. This indicates a loss of relative functional importance of the posterior brain regions and posterior functional hubs are thus disproportionally affected. Conclusions: Concluding, we observed a gradually decreasing functional connectivity in posterior regions with increasing AD severity, which was accompanied by a shifted hub location from posterior to central regions.