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O3‐04‐01: Targeting a stress‐associated hsp90 complex as a novel therapeutic strategy to downregulate toxic tau in Alzheimer's disease
Author(s) -
Chiosis Gabriela
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.254
Subject(s) - hsp90 , proteostasis , neurodegeneration , downregulation and upregulation , hsp90 inhibitor , in vivo , biology , microbiology and biotechnology , chaperone (clinical) , heat shock protein , cancer research , disease , biochemistry , medicine , genetics , pathology , gene
use mix. APOE ε4 carriers showed larger increases in ventricle volume and decreases in right-hippocampal volumes if living in neighborhoods with low street intersection density and land use mix, respectively. Significant increases in amyloid b burden were found only in APOE ε4 carriers from areas with below-average dwelling and intersection densities (Table 2). Conclusions: These preliminary findings indicate possible associations of urban environment characteristics with brain imaging measures, especially in those with a higher genetic risk. Further investigations are warranted.